Ilse Vanhorebeek Selected Research

Critical Illness (Critically Ill)

12/2022	Impact of critical illness and withholding of early parenteral nutrition in the pediatric intensive care unit on long-term physical performance of children: a 4-year follow-up of the PEPaNIC randomized controlled trial.
6/2022	Impact of duration of critical illness and level of systemic glucocorticoid availability on tissue-specific glucocorticoid receptor expression and actions: A prospective, observational, cross-sectional human and two translational mouse studies.
5/2022	Development and validation of clinical prediction models for acute kidney injury recovery at hospital discharge in critically ill adults.
1/2022	Phasing out DEHP from plastic indwelling medical devices used for intensive care: Does it reduce the long-term attention deficit of critically ill children?
1/2022	DNA methylation alterations in muscle of critically ill patients.
1/2022	C-reactive protein rise in response to macronutrient deficit early in critical illness: sign of inflammation or mediator of infection prevention and recovery.
1/2021	Role of age of critically ill children at time of exposure to early or late parenteral nutrition in determining the impact hereof on long-term neurocognitive development: A secondary analysis of the PEPaNIC-RCT.
1/2021	Differential DNA methylation by early versus late parenteral nutrition in the PICU: a biological basis for its impact on emotional and behavioral problems documented 4 years later.
1/2021	Supplementation of vitamins, trace elements and electrolytes in the PEPaNIC Randomised Controlled Trial: Composition and preparation of the prescription.
10/2020	Time course of altered DNA methylation evoked by critical illness and by early administration of parenteral nutrition in the paediatric ICU.

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Ilse Vanhorebeek Research Topics

Disease

90	Critical Illness (Critically Ill) 12/2022 - 12/2004
25	Hyperglycemia 01/2020 - 01/2005
12	Infections 01/2022 - 01/2014
9	Hypoglycemia (Reactive Hypoglycemia) 06/2015 - 07/2007
7	Inflammation (Inflammations) 01/2022 - 01/2005
5	Sepsis (Septicemia) 05/2022 - 01/2007
3	Acute Kidney Injury (Acute Renal Failure) 06/2017 - 03/2008
3	Mitochondrial Diseases (Mitochondrial Disease) 10/2015 - 04/2009
3	Burns 09/2009 - 04/2006
2	Wounds and Injuries (Trauma) 05/2022 - 10/2018
2	Fibrosis (Cirrhosis) 01/2022 - 02/2017
2	Starvation 01/2020 - 02/2012
2	Obesity 02/2017 - 02/2017
2	Insulin Resistance 02/2017 - 12/2009
2	Body Weight (Weight, Body) 02/2017 - 06/2008
2	Reperfusion Injury 06/2015 - 07/2010
1	Glucocorticoid Receptor Deficiency 06/2022
1	Cerebral Malaria 11/2019
1	Malaria 11/2019
1	Muscle Weakness 11/2019
1	Bacterial Infections (Bacterial Infection) 08/2019
1	Invasive Fungal Infections 08/2019
1	Malnutrition (Nutritional Deficiencies) 06/2019
1	Cross Infection (Nosocomial Infection) 10/2018
1	Multiple Organ Failure (MODS) 10/2017
1	Alcoholic Fatty Liver 02/2017
1	Hypercholesterolemia 02/2017
1	Ischemia 06/2015
1	Brain Injuries (Brain Injury) 02/2015
1	Seizures (Absence Seizure) 02/2015
1	Neoplasms (Cancer) 01/2014

Drug/Important Bio-Agent (IBA)

44	Insulin (Novolin)FDA Link 01/2022 - 01/2005
18	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 08/2005
15	Blood Glucose (Blood Sugar)IBA 01/2018 - 01/2006
8	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2005
7	LipidsIBA 11/2017 - 01/2005
6	Hormones (Hormone)IBA 01/2022 - 12/2004
5	Amino Acids FDA Link 01/2018 - 05/2012
4	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2020 - 09/2008
4	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2020 - 10/2006
3	GlucocorticoidsIBA 06/2022 - 09/2008
3	CreatinineIBA 09/2009 - 03/2008
2	Protein Isoforms (Isoforms)IBA 06/2022 - 08/2008
2	Biomarkers (Surrogate Marker)IBA 05/2022 - 10/2010
2	Biological ProductsIBA 01/2022 - 01/2021
2	C-Reactive ProteinIBA 01/2022 - 02/2015
2	CytokinesIBA 01/2022 - 02/2015
2	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2020 - 04/2013
2	Insulin-Like Growth Factor Binding ProteinsIBA 11/2019 - 08/2011
2	Insulin-Like Growth Factor I (IGF-1)IBA 11/2019 - 08/2011
2	Thyroid HormonesIBA 01/2019 - 02/2012
2	Glucagon (Glukagon)FDA Link 11/2017 - 08/2011
2	Mannose-Binding Lectin (Mannan-Binding Lectin)IBA 01/2016 - 01/2014
2	LectinsIBA 01/2016 - 01/2014
2	Peptide Hydrolases (Proteases)FDA Link 02/2015 - 01/2012
2	Messenger RNA (mRNA)IBA 01/2012 - 02/2010
2	Arginine (L-Arginine)FDA Link 08/2008 - 06/2008
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 06/2022
1	Cortisone ReductaseIBA 06/2022
1	PlasticizersIBA 01/2022
1	Diethylhexyl Phthalate (DEHP)IBA 01/2022
1	CalciumIBA 01/2022
1	PlasticsIBA 01/2022
1	MicronutrientsIBA 01/2021
1	1,25-dihydroxyvitamin DIBA 03/2020
1	hydroxide ionIBA 03/2020
1	25-hydroxyvitamin DIBA 03/2020
1	Vitamin D-Binding ProteinIBA 03/2020
1	Carrier Proteins (Binding Protein)IBA 01/2020
1	Indicators and Reagents (Reagents)IBA 01/2020
1	Dexamethasone (Maxidex)FDA LinkGeneric 11/2019
1	Mannose ReceptorIBA 08/2019
1	HLA-DR Antigens (HLA-DR)IBA 10/2018
1	HLA Antigens (Human Leukocyte Antigens)IBA 10/2018
1	Glutamine (L-Glutamine)FDA Link 01/2018
1	Lipocalin-2IBA 06/2017
1	Losartan (Cozaar)FDA LinkGeneric 02/2017
1	Sucrose (Saccharose)IBA 02/2017
1	CollagenIBA 02/2017
1	Serine Proteases (Serine Protease)IBA 01/2016
1	fibroblast growth factor 21IBA 10/2015
1	Receptor for Advanced Glycation End ProductsIBA 02/2015
1	LigandsIBA 02/2015
1	Hypoglycemic Agents (Hypoglycemics)IBA 02/2015
1	HMGB1 Protein (HMG1)IBA 02/2015
1	S100A12 ProteinIBA 02/2015
1	Mannose-Binding Protein-Associated Serine Proteases (Mannose-Binding Protein-Associated Serine Protease)IBA 01/2014
1	FicolinsIBA 01/2014

Therapy/Procedure

34	Parenteral Nutrition 12/2022 - 04/2009
29	Therapeutics 05/2014 - 01/2005
19	Glycemic Control 01/2018 - 01/2005
12	Critical Care (Surgical Intensive Care) 01/2022 - 10/2006
6	Enteral Nutrition (Feeding, Tube) 01/2021 - 05/2013
2	Renal Replacement Therapy (Therapies, Renal Replacement) 05/2022 - 03/2008
1	Muscle Denervation 01/2022
1	Artificial Respiration (Mechanical Ventilation) 01/2017
1	Punctures 09/2015
1	Ligation 09/2015
1	Cardiopulmonary Bypass (Heart-Lung Bypass) 06/2015
1	Analgesia 02/2015